Potential Effect of Syzygium aromaticum (Cloves) Extract on Serum Antioxidant Status and Lipid Profiles in Wistar Rats with Artesunate Toxicity

Artesunate toxicity has been linked to increased production of reactive oxygen species resulting in oxidative stress, which implicated the pathogenesis many chronic diseases. This study evaluated effects hydroethanolic extract Syzygium aromaticum buds (HESAB) on serum antioxidant status and lipid profiles Wistar rats with artesunate toxicity. Forty-eight male (150–200 g) randomized into six groups (n = 8) were treated as follows for 21 days: Group 1 (Control; DMSO); 2 (Artesunate, 15 mg/kg only); 3 (HESAB only, 400 mg/kg); 4 800 5 + HESAB, 6 mg/kg). Antioxidant parameters—such malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), glutathione (GSH), peroxidase (GPx), catalase (CAT)—were assayed using established methods. Serum profiles—which include total cholesterol (TC), triglyceride (TAG), high-density lipoprotein (HDL), low-density (LDL) assays—were performed kits. The findings showed a significant increase profile artesunate-induced group compared control groups. Administration HESAB reversed toxic artesunate. levels TC (69.42 ± 8.03 mg/dL, TAG (34.43 6.04 mg/dL), LDL (45.1 9.66 mg/dL) untreated significantly higher than (41.42 7.57 (28.18 1.58 (27.73 5.00 mg/dL). however was reduced diseased (artesunate) MDA, NO, GSH 5.032 1.25 µmol/L, 10.65 3.84 0.20 0.145 ?M respectively 2.237 0.95 6.20 2.21 0.49 0.068 respectively. Treatment raised level 0.38 0.19 ?M. Furthermore, CAT, SOD, GPX 7.62 2.15, 2.76 1.52, 3.54 1.91 ?mol/mL 19.03 4.25, 8.05 2.91, 10.62 3.24 18.866 2.59, 5.020 0.89, 5.05 2.01 In conclusion, caused decrease rats’ while administration S. bud lowered status.